|
KMID : 0812020060120010019
|
|
Korean Journal of Neurogastroenterology and Motility
2006 Volume.12 No. 1 p.19 ~ p.24
|
|
|
Dilated Intercellular Spaces of Esophageal Epithelium in Korean Reflux Esophagitis and Its Reversibility after Esomeprazole Treatment
|
|
Kim Jae-Hwan
Park Sung-Jae
Jee Sam-Ryong
Lee Youn-Jae
Lee Sang-Hyuk
Chung Jung-Myung
Seol Sang-Young
Park Eun-Taek
Yang Sung-Yoen
|
|
|
Abstract
|
|
|
Background/Aims: It has been demonstrated that dilated intercellular spaces of esophageal epithelium are a marker of tissue injury in Western gastroesophageal reflux disease (GERD); which heals after proton pump inhibitor (PPI) treatment. The aim of this study was to determine whether dilated intercellular spaces are also a feature of acid damage in Korean GERD patients and are also healed after PPI treatment.
Methods: Ten GERD patients with heartburn and esophageal mucosal breaks on endoscopy, and 10 controls with no symptoms, normal mucosa on endoscopy and negative 24-hour pH monitoring were enrolled. During upper gastrointestinal endoscopy, four biopsies from normal mucosa were taken within the lower 5 cm of the esophagus for transmission electron microscopy (TEM) analysis. One hundred computer measurements were taken on TEM photomicrographs of the specimens in each patient. After eight weeks of esomeprazole 40 mg/day, patients with erosive esophagitis had another endoscopy with biopsies and the intercellular spaces were measured again.
Results: The mean intercellular space diameter, in the erosive esophagitis patients, was greater than in controls (1.49±0.10 ㎛ vs 0.49±0.10 ㎛, p<0.01). The mean intercellular space diameter, in erosive esophagitis patients, improved after PPI treatment.
Conclusions: Korean erosive esophagitis patients have dilated intercellular spaces of esophageal epithelium and dilated intercellular spaces can be reversed after esomeprazole treatment. (Kor J Neurogastroenterol Motil 2006;12:19-24)
|
|
|
KEYWORD
|
|
|
GERD, Dilated intercellular spaces, Proton pump inhibitor, Reversibility
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|